HCID 18422335、化合物 → Ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate

HRID 649913

反応式

HRID 649913 の反応式
[F:1][C:2]1[C:22]([F:23])=[CH:21][C:5]([NH:6][C:7]2[S:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]=2[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:4]([N+:24]([O-])=O)[CH:3]=1.[H][H]>[C].[Pd].C(OCC)(=O)C>[NH2:24][C:4]1[CH:3]=[C:2]([F:1])[C:22]([F:23])=[CH:21][C:5]=1[NH:6][C:7]1[S:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[C:8]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

参加物

5

反応物 2

HCID 18422335HCID 18422335、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 18422150Ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

In the same manner as in Starting Material Synthesis Example 19 and using ethyl 2-(4,5-difluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate, ethyl acetate, 10% palladium-carbon and hydrogen (60 atm kg/cm2), ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate is obtained.

後処理

  1. customMaterial Synthesis Example 19

出典と根拠

ORDレコード
ord-741d1522726841718ffdca641334de7e
出典データセット
uspto-grants-2001_08
特許番号
US06271225B1

関連ノート

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