Ethyl 2-(5-fluoro-2-nitroanilino)-6-methylbenzo[b]thiophene-3-carboxylate → Ethyl 2-(2-amino-5-fluoroanilino)-6-methylbenzo[b]thiophene-3-carboxylate

HRID 649915ノート

反応式

HRID 649915 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:24]([O-])=O)=[C:6]([CH:23]=1)[NH:7][C:8]1[S:12][C:11]2[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:10]=2[C:9]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19].[H][H]>[C].[Pd].C(OCC)(=O)C>[NH2:24][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:23][C:6]=1[NH:7][C:8]1[S:12][C:11]2[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:10]=2[C:9]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19]

参加物

5

反応物 2

HCID 18422188Ethyl 2-(5-fluoro-2-nitroanilino)-6-methylbenzo[b]thiophene-3-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 18422258Ethyl 2-(2-amino-5-fluoroanilino)-6-methylbenzo[b]thiophene-3-carboxylate収率 88.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

In the same manner as in Starting Material Synthesis Example 19 and using ethyl 2-(5-fluoro-2-nitroanilino)-6-methylbenzo[b]thiophene-3-carboxylate (1.9 g), ethyl acetate (200 ml), 10% palladium-carbon (0.4 g) and hydrogen (60 atm kg/cm2), ethyl 2-(2-amino-5-fluoroanilino)-6-methylbenzo[b]thiophene-3-carboxylate (1.54 g) was obtained.

後処理

  1. customMaterial Synthesis Example 19

出典と根拠

ORDレコード
ord-8f52923cd0844e51bb10a7cbbcc0387f
出典データセット
uspto-grants-2001_08
特許番号
US06271225B1

反応ノート

読み込み中…