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Hydrochloric Acid → Ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | Stannous cation | HCID 104883 | — |
| 反応物 | Ethyl 2-amino-6-methylbenzo[b]thiophene-3-carboxylate | HCID 18422153 | — |
| 反応物 | Ethyl 6-methyl-2-(2-nitroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422322 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate | HCID 18422261 | — |
反応手順
In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-amino-6-methylbenzo[b]thiophene-3-carboxylate (4.18 g), 2-fluoronitrobenzene (2.5 g) and dimethyl sulfoxide (50 ml), crude crystals (7.5 g) of ethyl 6-methyl-2-(2-nitroanilino)benzo[b]thiophene-3-carboxylate were obtained. Without purification, in the same manner as in Starting Material Synthesis Example 21 and using ethanol (50 ml), 18% hydrochloric acid (70 ml) and tin(II) chlorihe.dihydrate (16 g), ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate (3.7 g) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06271225B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-25e82fd7efdf443e972511b6509aa9e0 |
| 出典メモ | uspto-grants-2001_08 |