化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Ethyl 2-(2-amino4,5-dichloroanilino)benzo[b]thiophene-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2,4,5-Trichloronitrobenzene | HCID 6983 | — |
| 反応物 | Stannous cation | HCID 104883 | — |
| 反応物 | Ethyl 2-amino-1-benzothiophene-3-carboxylate | HCID 699464 | — |
| 反応物 | Ethyl 2-(4,5-dichloro-2-nitroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422321 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 2-(2-amino4,5-dichloroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422259 | — |
反応手順
In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-aminobenzo[b]thiophene-3-carboxylate (6.0 g), 2,4,5-trichloronitrobenzene (6.8 g) and dimethyl sulfoxide (70 ml), crude crystals (10.3 g) of ethyl 2-(4,5-dichloro-2-nitroanilino)benzo[b]thiophene-3-carboxylate were obtained. Without purification, in the same manner as in Starting Material Synthesis Example 21 and using ethanol (100 ml), 18% hydrochloric acid (100 ml) and tin(II) chlorihe.dihydrate (22.8 g), ethyl 2-(2-amino4,5-dichloroanilino)benzo[b]thiophene-3-carboxylate (5.3 g) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06271225B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-bae2b5fabbff4958b6a11fea86e5a88f |
| 出典メモ | uspto-grants-2001_08 |