Hydrochloric Acid → Ethyl 2-(6-amino-2,3-dichloroanilino)benzo[b]thiophene-3-carboxylate

HRID 649927

反応式

HRID 649927 の反応式
NC1SC2C=CC=CC=2C=1C(OCC)=O.ClC1C(Cl)=C(Cl)C=CC=1[N+]([O-])=O.[Cl:28][C:29]1[C:49]([Cl:50])=[CH:48][CH:47]=[C:46]([N+:51]([O-])=O)[C:30]=1[NH:31][C:32]1[S:36][C:35]2[CH:37]=[CH:38][CH:39]=[CH:40][C:34]=2[C:33]=1[C:41]([O:43][CH2:44][CH3:45])=[O:42].Cl.[Sn+2]>C(O)C.CS(C)=O>[NH2:51][C:46]1[C:30]([NH:31][C:32]2[S:36][C:35]3[CH:37]=[CH:38][CH:39]=[CH:40][C:34]=3[C:33]=2[C:41]([O:43][CH2:44][CH3:45])=[O:42])=[C:29]([Cl:28])[C:49]([Cl:50])=[CH:48][CH:47]=1

参加物

8

反応物 5

HCID 313Hydrochloric AcidHCID 286972,3,4-TrichloronitrobenzeneHCID 104883Stannous cationHCID 699464Ethyl 2-amino-1-benzothiophene-3-carboxylateHCID 18422195HCID 18422195、化合物

生成物 1

HCID 18422327Ethyl 2-(6-amino-2,3-dichloroanilino)benzo[b]thiophene-3-carboxylate

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 702Ethanol溶媒

実験手順

In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-aminobenzo[b]thiophene-3-carboxylate (6.6 g), 2,3,4-trichloronitrobenzene (7.0 g) and dimethyl sulfoxide (70 ml), crude crystals (12 g) of ethyl 2-(2,3-dichloro-6-nitroanilino)benzo[b]thiophene-3-carboxylate were obtained. Without purification, in the same manner as in Starting Material Synthesis Example 21 and using ethanol (40 ml), 18% hydrochloric acid (60 ml) and tin(II) chlorihe.dihydrate (24.6 g), ethyl 2-(6-amino-2,3-dichloroanilino)benzo[b]thiophene-3-carboxylate (4.2 g) was obtained.

後処理

  1. customMaterial Synthesis Example 4
  2. customwere obtained
  3. customWithout purification
  4. customMaterial Synthesis Example 21

出典と根拠

ORDレコード
ord-0fa18393955e4de78421b40daf32cca1
出典データセット
uspto-grants-2001_08
特許番号
US06271225B1

関連ノート

読み込み中…