関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tetramethyl orthocarbonate | HCID 74613 | — |
| 反応物 | 2-Aminobenzohydroxamic acid | HCID 79721 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Hydroxy-2-methoxyquinazolin-4(3H)-one | HCID 15582710 | 60% |
反応手順
A mixture of 22.8 g (0.15 mol) of o-aminobenzohydroxamic acid, 50 ml of methanol and 27.2 g (0.2 mol) of orthocarbonic acid tetramethyl ester was boiled under reflux for 2 hours and was then cooled to 5° C. The product which had crystallized out was filtered off with suction. 17 g (60% of theory) of 2-methoxy-3-hydroxy-3,4-dihyro-4-oxo-quinazoline were obtained in the form of colorless crystals having a melting point of 220° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04612305 |
|---|
| 出典データセット | uspto-grants-1986_09 |
|---|
| ORD ID | ord-0c54b1ea714148a496fa7a4b18046342 |
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| 出典メモ | uspto-grants-1986_09 |
|---|
