Water → 2-Bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one

HRID 650000ノート

反応式

HRID 650000 の反応式
[S:1]1[C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=[CH:2]1.[Br:16]Br.O>C(O)(=O)C>[Br:16][C:2]1[S:1][C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 18422172Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one

生成物 1

HCID 184221932-Bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one収率 80.7%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one (2 g) was suspended in acetic acid (30 ml) and a solution of bromine (1.5 g) in acetic acid (10 ml) was added dropwise over 30 minutes. The mixture was stirred at room temperature for 35 minutes and poured into water. The precipitated crystals were collected by filtration and washed with water and diisopropyl ether to give 2-bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one (2.2 g).

後処理

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with water and diisopropyl ether

出典と根拠

ORDレコード
ord-9668b277fa4642cf9e29602a5f9122bf
出典データセット
uspto-grants-2001_08
特許番号
US06271225B1

反応ノート

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