Acetic acid, 2-(4-formylphenoxy)- → Pyrimidin-2,4-dione, 6-amino-5-[(4-carboxymethoxy)benzimidoyl]-1,3-dipr

HRID 65002

反応式

HRID 65002 の反応式
[C:1]([CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=O)=[CH:8][CH:7]=1)([OH:3])=[O:2].[NH2:14][C:15]1[C:16](=[O:29])[N:17]([CH2:26][CH2:27][CH3:28])[C:18](=[O:25])[N:19]([CH2:22][CH2:23][CH3:24])[C:20]=1[NH2:21]>CO.C(O)(=O)C>[NH2:21][C:20]1[N:19]([CH2:22][CH2:23][CH3:24])[C:18](=[O:25])[N:17]([CH2:26][CH2:27][CH3:28])[C:16](=[O:29])[C:15]=1[N:14]=[CH:10][C:9]1[CH:12]=[CH:13][C:6]([O:5][CH2:4][C:1]([OH:3])=[O:2])=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 89177Acetic acid, 2-(4-formylphenoxy)-HCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione

生成物 1

HCID 614654Pyrimidin-2,4-dione, 6-amino-5-[(4-carboxymethoxy)benzimidoyl]-1,3-dipr

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 887Methanol溶媒

実験手順

A representative synthesis of benzylidene adduct is given. Compound A (1.51 g, 8.37 mmol) was dissolved in a mixture of methanol (35 ml) and acetic acid (5 ml) in a 50 ml boiling flask on a steam bath. To this was added a methanolic solution (60 ml) of freshly synthesized 5,6-diamino-1,3-dipropyluracil. After heating 15 minutes, the volume was reduced by evaporation until crystallization occurred. Ether (40 ml) was added and the nearly white solid was collected. Yield 2.80 g (86%), mp 179°-180° C. Analysis (C19H24N4O5): calc. 58.60% C, 6.21% H, 14.39% N; found 58.72% C, 6.16% H, 14.43% N.

後処理

  1. customA representative synthesis of benzylidene adduct
  2. temperatureAfter heating 15 minutes
  3. customthe volume was reduced by evaporation until crystallization
  4. additionEther (40 ml) was added
  5. customthe nearly white solid was collected

出典と根拠

ORDレコード
ord-a7d385ad8eba4da9bf9d492fd1a5c7a1
出典データセット
uspto-grants-1986_09
特許番号
US04612315

関連ノート

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