(S)-(-)-1-Phenylethyl isocyanate → (S)-N-(2-hydroxy-4-nitrophenyl)-N'-(methyl benzyl)urea

HRID 650093ノート

反応式

HRID 650093 の反応式
[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:12][C@H:13]([N:20]=[C:21]=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:21]([NH:20][C@@H:13]([CH3:12])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:22]

参加物

3

反応物 2

HCID 2724173(S)-(-)-1-Phenylethyl isocyanateHCID 49847212-Amino-5-Nitrophenol

生成物 1

HCID 54257898(S)-N-(2-hydroxy-4-nitrophenyl)-N'-(methyl benzyl)urea収率 76.7%

実験手順

(S)-N-(2-Hydroxy-4-nitrophenyl)-N′-(methylbenzyl)urea was prepared from 2-hydroxy 4-nitro aniline (308 mg, 2.0 mmol) and (S)-methyl benzyl isocyanate (2 mmol) according to the procedure in General Method A. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (462 mg, 76%). EI-MS m/z 300(M−H)−

後処理

  1. customThe product was purified by dilution with methylene chloride and precipitation with hexanes
  2. filtrationFiltering

出典と根拠

ORDレコード
ord-e32df085c64f4fd0ad5a97cc515a9f74
出典データセット
uspto-grants-2001_08
特許番号
US06271261B1

反応ノート

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