関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Chloro-2-(isocyanatomethyl)benzene | HCID 2733367 | — |
| 反応物 | 4-Amino-3-hydroxybenzonitrile | HCID 10197719 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-(2-Hydroxy-4-cyanophenyl)N'-(2-chlorobenzyl)urea | HCID 21714412 | 58.8% |
反応手順
To a solution of 2-chlorobenzylisocyanate (125.6 mg, 0.75 mmol) in DMF (1.0 ml), 2-hydroxy-4-cyanoaniline (100 mg, 0.75 mmol) was added. The reaction mixture was stirred at 80° C. for 16 hours. Chromatography of the resulting liquid on silica gel (50% Ethyl acetate/Hexane) gave desired product (80 mg, 58.8%). EI-MS m/z 302.8 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06271261B1 |
|---|
| 出典データセット | uspto-grants-2001_08 |
|---|
| ORD ID | ord-a28e45464f8b4e359c7ab98f98b4f3f1 |
|---|
| 出典メモ | uspto-grants-2001_08 |
|---|
