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Hydrochloric Acid → 3-Methyl-4-(3-acetyl-5-oxo-2-pyrazolin-1-yl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Ethyl 3-(4-carboxy-2-methylphenylhydrazono)-4-oxopentanoate | HCID 86751496 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Methyl-4-(3-acetyl-5-oxo-2-pyrazolin-1-yl)benzoic acid | HCID 15485087 | — |
反応手順
To a solution of a 5 g. (34 mmoles) of 3-methyl-4-[N′-(2-ethoxycarbonyl-1-acetylethylidene)hydrazino]benzoic acid in 25 ml. of ethanol and 25 ml. of water was added with stirring 34.3 ml. of a 1 M sodium carbonate solution. The mixture was stirred at room temperature for 24 hours. The resulting mixture was acidified to pH 3 with 6 M hydrochloric acid and the resulting solid was collected by filtration, washed with water and dried. The 3-methyl-4-(3-acetyl-5-oxo-2-pyrazolin-1-yl)benzoic acid has melting point of >250° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06271373B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-d1df5cda31824a5d94bced5112eb8bbb |
| 出典メモ | uspto-grants-2001_08 |