Indene → 2-[3,5-Bis(trifluoromethyl)phenyl]-1H-indene

HRID 650304ノート

反応式

HRID 650304 の反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.I[C:11]1[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:13]([C:21]([F:24])([F:23])[F:22])[CH:12]=1>CC([O-])=O.CC([O-])=O.[Pd+2].C(N(CC)CC)C>[F:18][C:17]([F:19])([F:20])[C:15]1[CH:16]=[C:11]([C:2]2[CH2:3][C:4]3[C:9]([CH:1]=2)=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH:12]=[C:13]([C:21]([F:22])([F:23])[F:24])[CH:14]=1

参加物

5

反応物 2

HCID 7219IndeneHCID 6309701-Iodo-3,5-bis(trifluoromethyl)benzene

生成物 1

HCID 120106252-[3,5-Bis(trifluoromethyl)phenyl]-1H-indene

試薬・触媒・溶媒 2

HCID 167845palladium(II) acetate触媒HCID 8471Triethylamine溶媒

実験手順

20 ml of triethylamine, 2.2 g (20 mmole) of indene, 6.8 g (20 mmole) of 1-iodo-3,5-bis(trifluoromethyl)-benzene and 0.134 g (0.6 mmole) and 0.134 g (0.6 mmole) of Pd(OAc)2 were stirred under relux for 12 h. After it all triethylamine was removed under reduced pressure. The residue was treated with the mixture 50 ml of water and 50 ml of diethyl ether.

後処理

  1. customAfter it all triethylamine was removed under reduced pressure
  2. additionThe residue was treated with the mixture 50 ml of water and 50 ml of diethyl ether

出典と根拠

ORDレコード
ord-f1e9133ef0e54f7295b0c949d591a90e
出典データセット
uspto-grants-2001_08
特許番号
US06271411B1

反応ノート

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