4-Hydroxybiphenyl → 4-Phenylbenzene-1-thiol

反応式

O[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.CN(C)C(Cl)=[S:17]>>[SH:17][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 71034-Hydroxybiphenyl

HCID 27871Dimethylthiocarbamoyl chloride

生成物 1

HCID 27604144-Phenylbenzene-1-thiol収率 39%

実験手順

The reaction of p-hydroxybiphenyl with dimethylthiocarbamoyl chloride followed by Newman-Kwart rearrangement and finally hydrolysis (see J. Het. Chem. 15, 281 (1978) and WO 96/25 936) affords 4-mercaptobiphenyl only in a yield of 39%.

後処理

customfollowed by Newman-Kwart rearrangement and finally hydrolysis (see J. Het. Chem. 15, 281 (1978) and WO 96/25 936)

出典と根拠

ORDレコード: ord-449312bae85e473ea90313a75110cecd
出典データセット: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06271415B1

反応ノート

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