化工社化工社 化学情報印刷レポート · 研究参考用
Hydrogen Peroxide → 1-(2-Hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | tert-Butanol | HCID 6386 | — |
| 反応物 | Sodium Sulfite | HCID 24437 | — |
| 反応物 | 1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine | HCID 98642 | — |
| 生成物 | 1-(2-Hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-one | HCID 21885057 | — |
反応手順
Aqueous hydrogen peroxide is added to a mixture of 1-oxyl-2,2,6,6-tetramethylpiperidin-4-one and ferrous chloride in tert-butyl alcohol at 30-60° C. Excess peroxide is decomposed with aqueous sodium sulfite. The organic layer is concentrated and the residue is purified by flash chromatography to afford the desired 1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06271377B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-bb1d4d89719a4906a6c0e22342c9e9e9 |
| 出典メモ | uspto-grants-2001_08 |