化工社化工社 化学情報印刷レポート · 研究参考用
Carbon Disulfide → 2-Thenyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon Disulfide | HCID 6348 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-(Chloromethyl)thiophene | HCID 69830 | — |
| 反応物 | (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline | HCID 13375506 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-Thenyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate | HCID 13687659 | 50% |
反応手順
In the same manner as described in Example 8 by using (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline (2.02 g), 2N NaOH (10 ml), CS2 (1.5 g), 2-Thenyl chloride (2.65 g), and 80% ethanol (50 ml), there is prepared the title compound (1.86 g, 50%) as white powder, [α]D20 +108.4° (c=1.0, methanol). NMR (CDCl3, δ): 4.84 (s, 2H, CSSCH2 -- ##STR8## Mass m/e: 374 (M+), 244 (M+ -- ##STR9##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04612317 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-05d2ece3443f4bf7b151e7c045d5cf27 |
| 出典メモ | uspto-grants-1986_09 |