4-Methyl-alpha-(4-methylphenyl)benzeneacetic acid → Benzeneacetic acid, 4-methyl-alpha-(4-methylphenyl)-, methyl ester

HRID 650523

反応式

HRID 650523 の反応式
[C:1]1([CH3:18])[CH:6]=[CH:5][C:4]([CH:7]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)[C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1.Cl.[CH3:20]O>CO>[C:14]1([CH3:17])[CH:13]=[CH:12][C:11]([CH:7]([C:4]2[CH:5]=[CH:6][C:1]([CH3:18])=[CH:2][CH:3]=2)[C:8]([O:10][CH3:20])=[O:9])=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 303144-Methyl-alpha-(4-methylphenyl)benzeneacetic acidHCID 21893726Hydrochloride methanol

生成物 1

HCID 6452857Benzeneacetic acid, 4-methyl-alpha-(4-methylphenyl)-, methyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of di-p-tolylacetic acid (4.90 g, 20.4 mmol) in methanol was treated with sat'd HCl/MeOH solution at room temperature. The mixture was stirred at room temperature (3 h). The solvent was removed in vacuo and the residue dissolved in dichloromethane and sodium bicarbonate solution. The aqueous layer was extracted with two additional portions of dichloromethane and the combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound (21). The crude product was used directly.

後処理

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue dissolved in dichloromethane
  3. extractionThe aqueous layer was extracted with two additional portions of dichloromethane
  4. washthe combined organic extracts were washed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-457f78703e844a13b2f9a4ea3ef6e8db
出典データセット
uspto-grants-2001_08
特許番号
US06274583B1

関連ノート

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