Catechol → 4-Bromocatechol

HRID 650537

反応式

HRID 650537 の反応式
[C:1]1([C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4])[OH:2].[Br-:9].[Br-].O1CCOCC1>CCOCC>[Br:9][C:6]1[CH:5]=[C:3]([OH:4])[C:1](=[CH:8][CH:7]=1)[OH:2]

参加物

4

反応物 2

HCID 289CatecholHCID 222259191,4-Dioxane dibromide

生成物 1

HCID 284874-Bromocatechol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

Catechol (11.0 g; 0.100 mol) is dissolved in 50 ml of ether and 29 g of freshly-prepared dioxane dibromide (Yanovskaya, Terent′ev and Belsn′kii), J. Gen. Chem. Vol. 22:1594 (1952)) is added slowly as a solution in 50 ml of ether. The organic solution is washed with water (3 times) and dried over MgSO4. The solvent is removed under reduced pressure to yield 4-bromocatechol as a red-brown oil. 1H NMR δ 5.52 (s, 1), 5.70 (s, 1), 6.74 (d, 1, J=8.74 Hz), 6.92 (dd, 1, J=8.3, 2.3 Hz), and 7.01 ppm (d, 1, J=2.6 Hz).

後処理

  1. washThe organic solution is washed with water (3 times)
  2. dry with materialdried over MgSO4
  3. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-7bf87f8b61204513b2f5c3656818076f
出典データセット
uspto-grants-2001_08
特許番号
US06274600B1

関連ノート

読み込み中…