Ethanol → 5-Ethoxy-2-pyrrolidinone

HRID 650651ノート

反応式

HRID 650651 の反応式
[C:1]1(=[O:7])[NH:5][C:4](=[O:6])[CH2:3][CH2:2]1.B([O-])=O.[Na+].[OH-].[K+].[CH2:14](O)[CH3:15]>Cl>[CH2:14]([O:6][CH:4]1[NH:5][C:1](=[O:7])[CH2:2][CH2:3]1)[CH3:15]

参加物

6

反応物 4

HCID 702EthanolHCID 11439SuccinimideHCID 14797Potassium HydroxideHCID 145326Sodium metaborate

生成物 1

HCID 35805555-Ethoxy-2-pyrrolidinone収率 55%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid触媒

反応条件

温度
0 °C

実験手順

At 0° C., 9.91 g of succinimide were charged initially in 415 ml of ethanol and a total of 5.53 g of sodium boranate was added a little at a time. At this temperature, every 15 minutes 2 to 3 drops of 2N ethanolic hydrogen chloride were added dropwise over 4½ hours. Subsequently, the mixture was acidified to pH 3 using more acid. After stirring for 1 hour at 0° C., the mixture was neutralized using 1% strength ethanolic potassium hydroxide solution and the mixture was stirred for a further 15 minutes and evaporated. The residue was taken up in water and extracted three times with dichloromethane. After drying over sodium sulphate and concentrating, 7.16 g (55% of theory) of γ-ethoxy-γ-butyrolactam were obtained.

後処理

  1. stirringthe mixture was stirred for a further 15 minutes
  2. customevaporated
  3. extractionextracted three times with dichloromethane
  4. dry with materialAfter drying over sodium sulphate
  5. concentrationconcentrating

出典と根拠

ORDレコード
ord-9a954078d2b940cfa340074bf2d486c1
出典データセット
uspto-grants-2001_08
特許番号
US06274613B1

反応ノート

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