Benzene → 2-Pyrrolidinone, 5-phenyl-

HRID 650652ノート

反応式

HRID 650652 の反応式
C(O[CH:4]1[NH:9][C:7](=[O:8])[CH2:6][CH2:5]1)C.S(=O)(=O)(O)O.[CH:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:15]1([CH:4]2[NH:9][C:7](=[O:8])[CH2:6][CH2:5]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

4

反応物 3

HCID 241BenzeneHCID 1118Sulfuric AcidHCID 35805555-Ethoxy-2-pyrrolidinone

生成物 1

HCID 956722-Pyrrolidinone, 5-phenyl-収率 100%

実験手順

At 0° C., 6.45 g of γ-ethoxy-γ-butyrolactam and 50 ml of concentrated sulphuric acid were charged initially, and 18.8 ml of benzene were added. After thawing, the mixture was stirred at room temperature for 4 days. For work-up, the mixture was poured onto ice, extracted three times with ethyl acetate and the combined extracts were washed once with water and once with saturated aqueous sodium chloride solution, dried and evaporated. 8.1 g (100% of theory) of γ-phenyl-γ-butyrolactam were obtained.

後処理

  1. additionFor work-up, the mixture was poured onto ice
  2. extractionextracted three times with ethyl acetate
  3. washthe combined extracts were washed once with water and once with saturated aqueous sodium chloride solution
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-8a49c0e611f346a5a0f65718dc975656
出典データセット
uspto-grants-2001_08
特許番号
US06274613B1

反応ノート

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