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Hydrochloric Acid → isoamyl 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 5-Benzoyl-6-(methylsulfanyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid | HCID 13687513 | — |
| 溶媒 | Isoamyl Alcohol | HCID 31260 | — |
| 生成物 | isoamyl 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate | HCID 20235111 | — |
反応手順
A solution of 300 mg of 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml of isoamyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue purified by chromatography on alumina, to yield isoamyl 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04612325 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-e4412cf6058946c0be3bb8a1147c64c7 |
| 出典メモ | uspto-grants-1986_09 |