化工社化工社 化学情報印刷レポート · 研究参考用
Phosgene → N-methyl-N-(oxan-4-yl)carbamoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-(Methylamino)tetrahydro-2H-pyran | HCID 6991950 | — |
| 生成物 | N-methyl-N-(oxan-4-yl)carbamoyl chloride | HCID 21709910 | — |
反応手順
248 g (2.5 mol) of phosgene, 96 g (0.83 mol) of N-methyl-N-(tetrahydro-2H-pyran-4-yl)amine and 84 g (0.83 mol) of triethylamine were reacted by the method of the process described in Intermediate 1.2. Yield 108 g. 1H NMR (250 MHz, in CDCl3): δ=1.60-1.95 (m, 4H), 2.94 and 3.01 (2 s, together 3H), 3.35-3.55 (rm, 2H), 3.95-4.10 (m, 2H), 4.27-4.46 (m, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06277790B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-caaf391666dc4bf88eab3ccb9cad41de |
| 出典メモ | uspto-grants-2001_08 |