Lactic Acid → Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

反応式

[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3].[C:7]([OH:11])(=[O:10])[CH2:8][OH:9]>>[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3].[C:7]([OH:11])(=[O:10])[CH2:8][OH:9]

参加物

反応物 2

HCID 612Lactic Acid

HCID 757Glycolic Acid

生成物 1

HCID 36797Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

実験手順

To 160 g (1.5 mol) of 85% lactic acid aqueous solution was added 38 g (0.5 mol) of glycolic acid and the mixture was subjected to heating under reduced pressure in nitrogen gas stream at 100° to 150° C./350 to 30 mmHg stepwise for 6 hours with removing distilled water, and then the resultant was subjected to a condensation reaction at 175° C./6 to 5 mmHg for 36 hours to give lactic acid-glycolic acid copolymer [monomer ratio: 75/25 (on a weight basis), average molecular weight: 14000, glass transition temperature: about 40 to 45° C⟧

後処理

temperatureto heating under reduced pressure in nitrogen gas stream at 100° to 150° C./350 to 30 mmHg stepwise for 6 hours
customwith removing
distillationdistilled water
customthe resultant was subjected to a condensation reaction at 175° C./6 to 5 mmHg for 36 hours

出典と根拠

ORDレコード: ord-5547344012814bd1b65ff94ab1c4cd64
出典データセット: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04612364

反応ノート

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参加物