4-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile → 3-Amino-6-chloro-2-(4-chloropyridine-2-carbonyl)-1-(ethoxycarbonyl)indole

反応式

[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.Br.Br[CH2:18][C:19]([C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][N:22]=1)=[O:20]>>[NH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:9][CH:8]=2)[N:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:18]=1[C:19]([C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][N:22]=1)=[O:20]

参加物

反応物 2

HCID 183678884-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile

HCID 230033492-Bromo-1-(4-chloro-pyridin-2-yl)-ethanone hydrobromide

生成物 1

HCID 183681773-Amino-6-chloro-2-(4-chloropyridine-2-carbonyl)-1-(ethoxycarbonyl)indole

実験手順

The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-[(ethoxycarbonyl)amino]benzonitrile (Example 1, step 1) and 2-(bromoacetyl)4-chloropyridine hydrobromide*.

出典と根拠

ORDレコード: ord-507a9214f99241078040323b3c30c341
出典データセット: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06277878B1

反応ノート

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