Potassium Carbonate → 9-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine

HRID 65110ノート

反応式

HRID 65110 の反応式
Cl.[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 136332160HCID 136332160、化合物

生成物 1

HCID 1363321599-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

1.0 g of 9-(1,3-di-n-octanoyloxy-2 propoxymethyl)guanine HCl suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over maganesium sulfate and evaporated to yield 9-(1,3-di-n-octanoyloxy-2-propoxy methyl)guanine as the free base.

後処理

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over maganesium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-06d9d6e24aa64ee1a180e02e8359c70e
出典データセット
uspto-grants-1986_09
特許番号
US04612314

反応ノート

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