化工社化工社 化学情報印刷レポート · 研究参考用
Methylamine hydrochloride → (S)-(1-Methylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine hydrochloride | HCID 6364545 | — |
| 反応物 | 2-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid | HCID 14540322 | — |
| 生成物 | (S)-(1-Methylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester | HCID 22850398 | — |
反応手順
Methylamine hydrochloride (1.2 mmol) and Boc-L-3-(4-thiazolyl)alanine (1.0 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, acid wash omitted) and the product used without further purification. Yield, 250 mg, 88%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06277877B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-0991791ec76a4a95a874a3d3b169645c |
| 出典メモ | uspto-grants-2001_08 |