1,4-Dioxane hydrochloride → (S)-2-Amino-3-(4-amino-phenyl)-N,N-dimethyl-propionamide dihydrochloride

反応式

C(OC(=O)[NH:7][C@H:8]([C:17](=[O:21])[N:18]([CH3:20])[CH3:19])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=1)(C)(C)C.[ClH:23].O1CCOCC1>>[ClH:23].[ClH:23].[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:11]=[CH:12][C:13]([NH2:16])=[CH:14][CH:15]=1)[C:17]([N:18]([CH3:20])[CH3:19])=[O:21]

参加物

反応物 2

HCID 204431481,4-Dioxane hydrochloride

HCID 20679220(S)-[2-(4-Amino-phenyl)-1-dimethylcarbamoyl-ethyl]-carbamic acid tert-butylester

生成物 1

HCID 69688157(S)-2-Amino-3-(4-amino-phenyl)-N,N-dimethyl-propionamide dihydrochloride

反応条件

温度: 25 °C

実験手順

(S)-[2-(4-Amino-phenyl)-1-dimethylcarbamoyl-ethyl]-carbamicacidtert-butyl ester (214 mg, 0.7 mmol) was dissolved in 4M HCl-dioxane (2 mL) at 0° C. and the solution stirred for 2 hours at 25° C. The mixture was concentrated and the residue triturated with ether. Yield, 294 mg, 102%; PBMS 208 (MH+, 100%).

後処理

concentrationThe mixture was concentrated
customthe residue triturated with ether
customYield

出典と根拠

ORDレコード: ord-b9b0b5974e93460593f803e1fe51355f
出典データセット: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06277877B1

反応ノート

読み込み中…

参加物