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HRID 651150作成日：2026年10月26日

Dimethylamine, hydrochloride → (S)-(1-Dimethylcarbamoyl-3-phenyl-propyl)-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/651150

反応式

関与物質

役割名称HCID仕込み量
反応物Dimethylamine, hydrochlorideHCID 10473—
反応物(2S)-2-(((tert-butoxy)carbonyl)amino)-4-phenylbutanoic acidHCID 7018726—
溶媒dichloromethane N,N-dimethylformamideHCID 22350042—
生成物(S)-(1-Dimethylcarbamoyl-3-phenyl-propyl)-carbamic acid tert-butyl esterHCID 54369423—

反応手順

Dimethylamine hydrochloride (1.0 mmol) and (S)-N-t-butoxycarbonyl-2-amino-4-phenylbutyric acid (0.84 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, 3:1 dichloromethane/DMF reaction solvent) giving the product which was used without further purification. Yield 238 mg, 93%; HPLC (60/40) 5.98 minutes (97%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06277877B1
出典データセットuspto-grants-2001_08
ORD IDord-d0fc4e6efbfc443a85206233028fb153
出典メモuspto-grants-2001_08