((1S)-1-Methylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester → HCID 13689669、化合物
反応式
C(OC(=O)[NH:7][C@H:8]([C:16](=[O:19])[NH:17][CH3:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.[ClH:21].O1CCOCC1>>[ClH:21].[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:16]([NH:17][CH3:18])=[O:19]参加物
3
実験手順
[((1S)-1-Methylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester (2.35 g, 8.45 mmol) was dissolved in 4 M HCl-dioxane (20 ml) at 25° C. for 2 hours. The mixture was concentrated and the residue triturated with ether, and dried. Yield 1.70 g, 94%.
後処理
- concentrationThe mixture was concentrated
- customthe residue triturated with ether
- customdried
出典と根拠
- ORDレコード
- ord-5711be03a56f432985d3a62eb8c8e864
- 出典データセット
- uspto-grants-2001_08
- 特許番号
- US06277877B1
反応ノート
読み込み中…