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Itaconic acid → 3-(Benzothiazol-2-ylthio)-propane-1,2-dicarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Itaconic acid | HCID 811 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | HCID 178418395 | HCID 178418395 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-(Benzothiazol-2-ylthio)-propane-1,2-dicarboxylic acid | HCID 19427537 | 50.5% |
反応手順
13.3 g of AlCl3 are dissolved in 100 ml of diethyl ether at 0° to 5°. 3.4 g of 2-mercaptobenzothiazole and 2.6 g of itaconic acid are then added. After the mixture has been stirred at 20°-25° for 24 hours, the ether solution is poured off and the residue is stirred with 100 ml of water and 100 ml of ethyl acetate. The organic phase is separated off, dried and evaporated. 3 g of 3-(benzothiazol-2-ylthio)-propane-1,2-dicarboxylic acid are obtained as the residue.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04612378 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-7b1fd30bd3da47a381b20f84f472db06 |
| 出典メモ | uspto-grants-1986_09 |