関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | D-Aspartic Acid | HCID 83887 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-Methyl hydrogen D-aspartate hydrochloride | HCID 56828183 | 78% |
反応手順
A suspension of D-aspartic acid (10.0 g, 75.1 mmol) in 50 mL methanol is treated with thionyl chloride (8.94 g, 75.1 mmol) at 0° C. The reaction mixture is stirred at 0° C. for 30 min, then at RT for 2 h. The resulting clear solution is diluted with 200 mL diethyl ether with rapid stirring. A white precipitate is formed which is collected by vacuum filtration, washed with diethyl ether and dried to yield 10.7 g (78%) of D-aspartic acid β-methyl ester hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06277987B1 |
|---|
| 出典データセット | uspto-grants-2001_08 |
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| ORD ID | ord-5703d2ade3af4408a9da08641f6e1006 |
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| 出典メモ | uspto-grants-2001_08 |
|---|
