化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl alpha-oxobenzenebutanoate → Ethyl 2-hydroxy-4-phenylbutyrate, (+-)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl alpha-oxobenzenebutanoate | HCID 562087 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 溶媒 | Toluene methanol | HCID 21867641 | — |
| 生成物 | Ethyl 2-hydroxy-4-phenylbutyrate, (+-)- | HCID 4092621 | — |
反応手順
The general procedure described in Example B1 is repeated, with the following modifications to the reaction conditions: ethyl-4-phenyl-2-oxobutyrate (substrate): 0.352 g (1.7 mmol); solvent: 10 ml of toluene/methanol (1:1); hydrogen: 50 bar, temperature: 50° C.; reaction time: 19 hours. The conversion is 100%, ee: 44% (R).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE037344E1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-2a15d83e4c9a44eea74e25d3e9238d39 |
| 出典メモ | uspto-grants-2001_08 |