Nor-HN2 → HCID 21708342、化合物

HRID 651383ノート

反応式

HRID 651383 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[C:10]([F:13])([F:12])[F:11].[Cl-].Cl[CH2:16][CH2:17][NH2+:18][CH2:19][CH2:20]Cl>C(O)CCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:5][C:4]=1[C:10]([F:11])([F:12])[F:13]

参加物

4

反応物 2

HCID 13186Nor-HN2HCID 6007055-Amino-2-methoxybenzotrifluoride

生成物 1

HCID 21708342HCID 21708342、化合物

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A mixture of 4-methoxy-3-trifluoromethylphenylamine (12 g; 0.0627 mol) and bis(2-chloroethyl) ammonium chloride (11.2 g; 0.0627 mol) in n-butanol (120 ml) was refluxed for 10 hours. The reaction mixture was cooled at room temperature and the crude title compound precipitated as hydrochloride salt overnight. The solid was collected and crystallized from acetone. 7 g; m.p. 244-245° C.

後処理

  1. temperaturewas refluxed for 10 hours
  2. customthe crude title compound precipitated as hydrochloride salt overnight
  3. customThe solid was collected
  4. customcrystallized from acetone

出典と根拠

ORDレコード
ord-77065d2ad7124cfb88d36133bbc78dd1
出典データセット
uspto-grants-2001_08
特許番号
US06281218B1

反応ノート

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