Methanesulfonic Acid → p-Acrylamidomethylphenethyl chloride

HRID 65139

反応式

HRID 65139 の反応式
[CH2:1]([Cl:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:10]([NH:12][C:13](=[O:16])[CH:14]=[CH2:15])O.CS(O)(=O)=O>>[C:13]([NH:12][CH2:10][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][CH2:1][Cl:9])=[CH:4][CH:5]=1)(=[O:16])[CH:14]=[CH2:15]

参加物

4

反応物 3

HCID 6395Methanesulfonic AcidHCID 13543N-MethylolacrylamideHCID 2314961-Chloro-2-phenylethane

生成物 1

HCID 20235265p-Acrylamidomethylphenethyl chloride収率 75%

反応条件

温度
15 °C

実験手順

70 parts (0.5 mole) of phenethyl chloride and 51.5 parts (0.51 mole) of N-methylolacrylamide are stirred, in succession, into 300 parts by volume of methanesulfonic acid which has been cooled to 15° C. Stirring is continued for 6 hours at from 15° to 20° C., and hydrolysis is effected by adding 1,500 parts of crushed ice. After the ice has thawed, the product is filtered off and dried in the air to give 84 parts (yield: 75%) of crude p-acrylamidomethylphenethyl chloride, which is recrystallized from methyl alcohol to give a pure product of melting point 145°-147° C.

後処理

  1. customis continued for 6 hours at from 15° to 20° C., and hydrolysis
  2. additionby adding 1,500 parts of crushed ice
  3. filtrationthe product is filtered off
  4. customdried in the air

出典と根拠

ORDレコード
ord-a09ae66e3614410880f3d764cf2e144f
出典データセット
uspto-grants-1986_09
特許番号
US04612392

関連ノート

読み込み中…