Ammonia → 2,2-Dimethyl-1,3-dioxan-5-amine

HRID 651410ノート

反応式

HRID 651410 の反応式
[CH3:1][C:2]1([CH3:9])[O:7][CH2:6][C:5](=O)[CH2:4][O:3]1.[NH3:10]>[Ni]>[CH3:1][C:2]1([CH3:9])[O:7][CH2:6][CH:5]([NH2:10])[CH2:4][O:3]1

参加物

4

反応物 2

HCID 222AmmoniaHCID 27331412,2-Dimethyl-1,3-dioxan-5-one

生成物 1

HCID 117686082,2-Dimethyl-1,3-dioxan-5-amine

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

6.1 g (47 mmol) of 2,2-dimethyl-1,3-dioxan-5-one (D. Enders, B. Bockstiegel, Synthesis 1989, 493, incorporated herein by reference) were subjected to reductive amination in 50 ml of ammonia—saturated methanol in an autoclave at 50° C. under a hydrogen pressure of 100 bar, using Raney nickel as the catalyst. After the catalyst had been filtered off and the filtrate concentrated, 4.8 g of a brown oil were obtained, this being further reacted without purification.

後処理

  1. customBockstiegel, Synthesis 1989, 493
  2. filtrationAfter the catalyst had been filtered off
  3. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-f2c76cee99944860a5030a738a043846
出典データセット
uspto-grants-2001_08
特許番号
US06281221B1

反応ノート

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