関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Methylurea | HCID 11719 | — |
| 反応物 | Ethyl 3,4-dimethoxybenzoylacetate | HCID 2758465 | — |
| 溶媒 | Tetralin | HCID 8404 | — |
| 生成物 | 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione | HCID 13714258 | 40.3% |
反応手順
To a solution of ethyl veratroylacetate (8.0 g) in tetralin (24 ml) was added N-methylurea (3.52 g) and the mixture was heated for an hour at 170° C. After being cooled to 95° C., ethyl acetate (33 ml) was added thereto. The precipitate was collected by filtration and washed with ethyl acetate to give 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione (3.35 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04612376 |
|---|
| 出典データセット | uspto-grants-1986_09 |
|---|
| ORD ID | ord-ac4b51625d934dca87d4af4f9d803b3c |
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| 出典メモ | uspto-grants-1986_09 |
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