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Carbon tetrabromide → (2-(2-Bromoethoxy)ethoxy)(tert-butyl)dimethylsilane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon tetrabromide | HCID 11205 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 2-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)ethanol | HCID 11117582 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (2-(2-Bromoethoxy)ethoxy)(tert-butyl)dimethylsilane | HCID 18185637 | 70.2% |
反応手順
18.2 g of carbon tetrabromide is added over 15 minutes at −15°/−20° C. to a mixture containing 11.2 g of the product of Stage A and 14.4 g of triphenylphosphine in 100 cm3 of methylene chloride. Agitation is carried out for 1 hour 15 minutes at −15° C., the solvent is evaporated off, followed by taking up in pentane, agitating at ambient temperature, separating, washing with pentane and drying at 50° C. under reduced pressure. 10.1 g of expected product is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06281204B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-bcb4d5119b454cbbad52625271afd587 |
| 出典メモ | uspto-grants-2001_08 |