5-Azaindole → HCID 54447290、化合物

HRID 651626ノート

反応式

HRID 651626 の反応式
[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[CH:2]1.Br[CH2:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>>[C:15]([O:14][C:12](=[O:13])[CH2:11][N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[CH:2]1)([CH3:18])([CH3:17])[CH3:16]

参加物

3

反応物 2

HCID 92205-AzaindoleHCID 79177tert-Butyl bromoacetate

生成物 1

HCID 54447290HCID 54447290、化合物

実験手順

The title compound is prepared from 1H-pyrrolo[3,2-c]pyridine as described in EXAMPLES 18 and 19, Part A using tert-butyl bromoacetate in place of methyl iodide. The crude product is purified by column chromatography eluting with a gradient of 3% MeOH/CH2Cl2 to 6% MeOH/CH2Cl2 to give the title compound as an oil.

後処理

  1. customThe crude product is purified by column chromatography
  2. washeluting with a gradient of 3% MeOH/CH2Cl2 to 6% MeOH/CH2Cl2

出典と根拠

ORDレコード
ord-b83882fafd474bdaa10245e91d475de6
出典データセット
uspto-grants-2001_08
特許番号
US06281227B1

反応ノート

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