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Malononitrile → Dihydro-2H-pyran-4,4(3H)-dicarbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Malononitrile | HCID 8010 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,1'-Oxybis(2,2-dichloroethane) | HCID 62383 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Dihydro-2H-pyran-4,4(3H)-dicarbonitrile | HCID 14537194 | — |
反応手順
According to Flowchart B dichloroethyl ether (7) and malononitrile (8) are reacted with potassium carbonate in acetonitrile at reflux, giving tetrahydro-4H-pyran-4,4-dicarbonitrile (9) which is then reacted with 1N borane in tetrahydrofuran followed by treatment with hydrochloric acid, giving tetrahydro-4H-pyran-4,4-dimethanamine dihydrochloride (10) which is then reacted with sodium acetate and potassium tetrachloroplatinate in water, giving the product (11).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06281365B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-9feac1c7d68d41e1a05a382e62012bcf |
| 出典メモ | uspto-grants-2001_08 |