反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[N:12](COCC[Si](C)(C)C)[CH:13]=[CH:14][N:15]=3)[CH:9]=2)[CH:4]=[CH:3]1.Cl.C([O:28][C:29](=[NH:41])[CH2:30][C:31]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[N:33]([CH3:40])[CH:32]=1)(C)C.Cl.[CH3:43][CH2:44][OH:45]>>[NH:12]1[CH:13]=[CH:14][N:15]=[C:11]1[C:8]1[CH:9]=[C:10]2[C:5]([C:4]([C:43]3[C:44](=[O:45])[NH:28][C:29](=[O:41])[C:30]=3[C:31]3[C:39]4[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=4)[N:33]([CH3:40])[CH:32]=3)=[CH:3][N:2]2[CH3:1])=[CH:6][CH:7]=1参加物
5
反応物 4
生成物 1
実験手順
3-[6-(1H-Imidazol-2-yl)-1-methyl-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione (37 mg, 14%) was prepared as an orange solid using 1-methyl-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1H-indole (200 mg, 0.61 mmol) and 1-methyl-3-indoleacetimidic acid isopropyl ester hydrochloride (162 mg, 0.61 mmol) followed by deprotection using 20% HCl in refluxing EtOH.
出典と根拠
- ORDレコード
- ord-1cf4dfeba95747aabc7cf86752aff57a
- 出典データセット
- uspto-grants-2001_08
- 特許番号
- US06281356B1
関連ノート
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