関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl chloroglyoxylate | HCID 79846 | — |
| 反応物 | 6-methoxy-1-methyl-1H-indole | HCID 4777929 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | methyl (6-methoxy-1-methyl-1H-indol-3-yl)glyoxylate | HCID 84741837 | 41% |
反応手順
6-Methoxy-1-methyl-1H-indole (1.0 g, 6.19 mmol) was dissolved in ether (10 mL) and cooled to 0° C. Methyl chlorooxoacetate (1.17 mL, 12.4 mmol) was added dropwise. Stirring was continued at 0° C. for 6 h. The mixture was filtered and washed well with ether to give methyl (6-methoxy-1-methyl-1H-indol-3-yl)glyoxylate (621 mg, 41%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06281356B1 |
|---|
| 出典データセット | uspto-grants-2001_08 |
|---|
| ORD ID | ord-ed957cc20c3948879785331dc05d89d3 |
|---|
| 出典メモ | uspto-grants-2001_08 |
|---|
