Water → Ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate

HRID 65180

反応式

HRID 65180 の反応式
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[O:3].[C:8](=[O:18])([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[NH2:9].O>C1(C)C=CC=CC=1>[CH2:11]([O:10][C:8]([NH:9][CH:2]([OH:3])[C:1]([O:5][CH2:6][CH3:7])=[O:4])=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 962WaterHCID 12136Benzyl carbamateHCID 70211Ethyl oxoacetate

生成物 1

HCID 20233481Ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate収率 64.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 17.3 g (0.169 mole) of ethyl glyoxylate and 23.0 g (0.152 mole) of benzyl carbamate in 250 ml of toluene was heated under reflux for 6 hours, with removal of water using a Dean-Stark trap. The resulting reaction mixture was concentrated in vacuo, and diethyl ether was added to the residue. The mixture was filtered, and the diethyl ether solution was evaporated in vacuo to give 25.0 g of ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate as a sticky solid.

後処理

  1. customThe resulting reaction mixture
  2. concentrationwas concentrated in vacuo, and diethyl ether
  3. additionwas added to the residue
  4. filtrationThe mixture was filtered
  5. customthe diethyl ether solution was evaporated in vacuo

出典と根拠

ORDレコード
ord-302a40ecef4448ebbe1ad41a616bb359
出典データセット
uspto-grants-1986_09
特許番号
US04613462

関連ノート

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