関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl Alcohol | HCID 244 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 2-Chloropropionic acid | HCID 11734 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 生成物 | 2-(Benzyloxy)propanoic acid | HCID 245987 | — |
反応手順
An alternate method for the preparation of ether compounds corresponding to Formula I (R=alkyl, phenylalkyl) follows. Sodium metal (about 12 g) was added cautiously to a stirred cold (ice bath) portion (250 mL) of benzyl alcohol. After most of the sodium metal had dissolved, the reaction was heated to 150° C. 2-Chloropropionic acid (27.2 g, 0.25 mole) was added dropwise in 35 mL of benzyl alcohol and the resulting mixture heated on additional 3 hours. Concentration in vacuo gave crude 2-benzyloxypropionic acid which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04613600 |
|---|
| 出典データセット | uspto-grants-1986_09 |
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| ORD ID | ord-fe9164041aa440dc9fdedea83fb7fb30 |
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| 出典メモ | uspto-grants-1986_09 |
|---|
