化工社化工社 化学情報印刷レポート · 研究参考用
25-Hydroxycholesterol → 25-Hydroxycholesta-1,4,6-trien-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 25-Hydroxycholesterol | HCID 65094 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 25-Hydroxycholesta-1,4,6-trien-3-one | HCID 22797387 | — |
反応手順
25-Hydroxycholesterol (3.4 gms) and dichlorodicyanoquinone (6.5 gms) dissolved in purified dioxan (100 mls) were heated at reflux for 20 hrs. The mixture was filtered and the solvent evaporated. Chromatography of the residue on alumina and elution with ethyl acetate and benzene afforded the trienone. Recrystallization from methanol gave the title compound, melting point 183°-184°. νmax. 3600, 1650 and 1600 cm-1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04670190 |
| 出典データセット | uspto-grants-1987_06 |
| ORD ID | ord-3c2068ef9cc742e1ade3feaa90bafb20 |
| 出典メモ | uspto-grants-1987_06 |