Allylamine → HCID 13747166、化合物
反応式
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[CH:9]=[N:10][NH:11][C:3]=12.[CH2:12]([NH2:15])[CH:13]=[CH2:14]>O>[CH2:12]([NH:15][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[CH:9]=[N:10][NH:11][C:3]=12)[CH:13]=[CH2:14]参加物
4
実験手順
A mixture of 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) (1.0 g, 0.006 mole) and allylamine (60 g) in water (100 ml) was heated under reflux for 12 days. On cooling the reaction mixture was evaporated to dryness, basified to pH8 with 10% sodium carbonate solution and the resulting solid filtered off. Recrystallisation from chloroform/pentane gave the product as white solid (1.0 g). m.p. 172°-174° C.
後処理
- temperaturewas heated
- temperatureunder reflux for 12 days
- temperatureOn cooling the reaction mixture
- customwas evaporated to dryness
- filtrationthe resulting solid filtered off
- customRecrystallisation from chloroform/pentane
出典と根拠
- ORDレコード
- ord-8ceafe762bf746c1b5531cc156e2df43
- 出典データセット
- uspto-grants-1987_06
- 特許番号
- US04670432
反応ノート
読み込み中…