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Dimethylformamide → 2-(2-Chlorophenyl)-3-dimethylaminoprop-2-enal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | o-Chlorophenylacetic acid | HCID 17124 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(2-Chlorophenyl)-3-dimethylaminoprop-2-enal | HCID 54209358 | — |
反応手順
73 g of dimethylformamide are cooled to -50° C. 92 g of phosphorus oxychloride are added dropwise, followed by 34.2 g of 2-chlorophenylacetic acid, and the reaction mixture is stirred at room temperature for 30 minutes. It is then heated at 70°-80° C. for 5 hours 30 minutes. The reaction mixture is rendered alkaline with potassium carbonate, 200 ml of toluene are added and the mixture is heated in a water bath for 1 hour.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04613603 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-9460d22982ec49918395afe4446371b9 |
| 出典メモ | uspto-grants-1986_09 |