化工社化工社 化学情報印刷レポート · 研究参考用
Dichloromethane → 1-(Methoxycarbonyl)propyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methyl 2-hydroxybutanoate | HCID 520445 | — |
| 反応物 | 4-[14-(Trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride | HCID 20198230 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-(Methoxycarbonyl)propyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate | HCID 20198267 | — |
反応手順
To a solution of 10.0 g. 4-[14-(trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride in 200 ml. methylene chloride is added dropwise a solution of 3 g. methyl α-hydroxybutyrate and 5 g. triethylamine in 100 ml. ether. After 17 hours stirring at room temperature, the precipitate is collected and washed with several portions of ether. The ether solution is washed with water, dried and evaporated to yield the product as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04670421 |
| 出典データセット | uspto-grants-1987_06 |
| ORD ID | ord-703c8991bd5548c08ffbd47fb47e00ab |
| 出典メモ | uspto-grants-1987_06 |