Hydrochloric Acid → HCID 20198263、化合物

HRID 652042ノート

反応式

HRID 652042 の反応式
[CH3:1][Si:2]([CH3:33])([CH3:32])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:31]=[CH:30][C:21]([C:22]([CH2:24][CH2:25][C:26]([O:28]C)=[O:27])=[O:23])=[CH:20][CH:19]=1.[OH-].[K+].C(O)C.Cl>O>[CH3:33][Si:2]([CH3:1])([CH3:32])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([CH2:24][CH2:25][C:26]([OH:28])=[O:27])=[O:23])=[CH:30][CH:31]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702Ethanol2 回HCID 14797Potassium HydroxideHCID 20198232HCID 20198232、化合物

生成物 1

HCID 20198263HCID 20198263、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 5.4 g. of methyl 3-[4-[14-(trimethylsilyl)tetradecylamino]benzoyl]propionate is stirred with 5.4 g. of potassium hydroxide in 100 ml. of 95% ethanol for 3 hours at reflux. The reaction mixture is cooled, diluted with 50 ml. of ethanol and 100 ml. of water, and neutralized with hydrochloric acid. The solution is cooled to room temperature and filtered. The white solid is washed with 50% aqueous ethanol and dried. The product is recrystallized to yield 3-[4-[14-(trimethylsilyl)tetradecylamino]benzoyl]propionic acid as a white crystalline solid.

後処理

  1. temperatureThe reaction mixture is cooled
  2. additiondiluted with 50 ml
  3. filtrationfiltered
  4. washThe white solid is washed with 50% aqueous ethanol
  5. customdried
  6. customThe product is recrystallized

出典と根拠

ORDレコード
ord-accc9ce6d8504295b2dfd32400a04e9e
出典データセット
uspto-grants-1987_06
特許番号
US04670421

反応ノート

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