関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Acetylthiourea | HCID 2723593 | — |
| 反応物 | Potassium cyanate | HCID 11378442 | — |
| 反応物 | 1-(4-Pyridyl)-1-bromo-2-butanone | HCID 20199218 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Ethyl-5-pyridin-4-yl-2(3H)thiazolone | HCID 20145016 | — |
反応手順
1-(4-Pyridyl)-1-bromo-2-butanone (28.8 g, 0.1 mol) and 1-acetyl-2-thiourea (13.0 g, 0.11 mol) are combined in 200 ml absolute ethanol and refluxed 24 hours. The solvent is evaporated and the residue is purified by chromatography. The thiol is mixed with (8.1 g, 0.1 mol) potassium cyanate and 0.2 mol 10% aqueous hydrochloric acid. The mixture is heated to 80° C. for 15 minutes, then cooled. The acid is adjusted to ph=6.5 with solid sodium bicarbonate which causes the product to precipitate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04670450 |
|---|
| 出典データセット | uspto-grants-1987_06 |
|---|
| ORD ID | ord-59335595239343ebbaf7e4fe817cfef8 |
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| 出典メモ | uspto-grants-1987_06 |
|---|
