4-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}aniline → 1,3-Dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]-2-thiobarbituric acid

HRID 652061ノート

反応式

HRID 652061 の反応式
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[S:4].[F:17][C:18]([F:34])([F:33])[C:19]1[CH:20]=[CH:21][C:22]([O:25][C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)=[N:23][CH:24]=1>CN(C)C=O>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:30][C:29]2[CH:31]=[CH:32][C:26]([O:25][C:22]3[CH:21]=[CH:20][C:19]([C:18]([F:34])([F:17])[F:33])=[CH:24][N:23]=3)=[CH:27][CH:28]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[S:4]

参加物

4

反応物 2

HCID 27830854-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}anilineHCID 140533471,3-Dimethyl-5-ethoxycarbonyl-2-thiobarbituric acid

生成物 1

HCID 140533611,3-Dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]-2-thiobarbituric acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2.5 g (10 mmol) of 1,3-dimethyl-5-ethoxycarbonyl-2-thiobarbituric acid, 2,55 g (10 mmol) of 4-(5-trifluoromethylpyrid-2-yloxy)aniline and 5 ml of dimethylformamide are stirred for 6 hours at 118° C. The reaction mixture is then cooled, triturated with water and the crystalline precipitate is isolated by filtration. The crude product is recrystallised from ethanol. Melting point 156°-158° C.

後処理

  1. temperatureThe reaction mixture is then cooled
  2. customtriturated with water
  3. customthe crystalline precipitate is isolated by filtration
  4. customThe crude product is recrystallised from ethanol

出典と根拠

ORDレコード
ord-1ece00a06c314f4e802ebf7efa6ecb2e
出典データセット
uspto-grants-1987_06
特許番号
US04670441

反応ノート

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