1-(4-Chlorophenyl)-2-butyn-1-ol → (Z)-1-(4-chlorophenyl)-2-buten-1-ol

HRID 65235

反応式

HRID 65235 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[C:9]#[C:10][CH3:11])=[CH:4][CH:3]=1>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:12])/[CH:9]=[CH:10]\[CH3:11])=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 201883391-(4-Chlorophenyl)-2-butyn-1-ol

生成物 1

HCID 67901371(Z)-1-(4-chlorophenyl)-2-buten-1-ol

試薬・触媒・溶媒 1

HCID 131709914Lindlars catalyst触媒

実験手順

Under nitrogen, hydrogenate a mixture of 10 g (0.055 mole) of 1-(4-chlorophenyl)-2-butyn-1-ol and 0.6 g Lindlar catalyst. Following the reaction vic NMR the reaction is complete in about two days. The hydrogenation is stopped and the reaction stirred under N2 at room temperature overnight. Filter off the catalysts, wash with methylene chloride combine the filtrate and evaporate to yield the title compound.

後処理

  1. filtrationFilter off the catalysts
  2. washwash with methylene chloride
  3. customevaporate

出典と根拠

ORDレコード
ord-1ba35f007e7240af90d3407e16dabfe8
出典データセット
uspto-grants-1986_09
特許番号
US04613609

関連ノート

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